ROLE OF INTEGRINS IN HUMAN SPERM CELLS ON THE REPRODUCTION PROCESS
DOI:
https://doi.org/10.37306/3f93t939Keywords:
cells, fertilization, moleculer, molekular, SpermAbstract
Ovum and spermatozoa cells, namely male and female reproductive cells that unite at the time of fertilization, are synchronized molecular events that occur sequentially. Apart from being present in the egg cell, adhesion molecules called integrins are also involved in this molecular process. However, recently, these integrins have also been found in spermatozoa cells, especially in the head and tail areas. Because this problem is intended as an introduction to the laboratory which is part of the thesis research, the method used in this research is a literature review whose publication age is not more than 10 years. Research findings indicate that integrins play a crucial role in egg-sperm recognition, their interaction, and fusion, potentially addressing infertility issues in couples of reproductive age.
Downloads
References
Al-dossary, A. A., & Martin-deleon, P. A. (2016). Role of exosomes in the reproductive tract oviductosomes mediate interactions of oviductal secretion with gametes/early embryo. Frontiers in Bioscience (Landmark Edition), 2, 1278–1285.
Ariki, R. D., & Ulandari, D. (2018). Hubungan Media Informasi, Pengaruh Teman, Tempat Tinggal dengan Pengetahuan Kesehatan Reproduksi pada Remaja di Kota Palembang Tahun 2017. Jurnal Kedokteran Dan Kesehatan, 14(2), 39. https://doi.org/10.24853/jkk.14.2.39-46
Aziza, N., & Hantono, D. (2023). Kesiapan Ibu Dalam Perannya Sebagai Pendidik Anak Untuk Mempersiapkan Masa Depan Bangsa. Raheema: Jurnal Studi Gender Dan Anak, 10(2), 34–42. https://doi.org/10.24260/raheema.v10i2.1710
Barraud-Lange, V., Naud-Barriant, N., Saffar, L., Gattegno, L., Ducot, B., Drillet, A.-S., Bomsel, M., Wolf, J.-P., & Ziyyat, A. (2007). Alpha6beta1 integrin expressed by sperm is determinant in mouse fertilization. BMC Developmental Biology, 7(1), 102. https://doi.org/10.1186/1471-213X-7-102
Fontenete, S., Peña-Jimenez, D., & Perez-Moreno, M. (2017). Heterocellular cadherin connections: coordinating adhesive cues in homeostasis and cancer. F1000Research, 6, 1010. https://doi.org/10.12688/f1000research.11357.1
Frolikova, M., Valaskova, E., Cerny, J., Lumeau, A., Sebkova, N., Palenikova, V., Sanches-Hernandez, N., Pohlova, A., Manaskova-Postlerova, P., & Dvorakova-Hortova, K. (2019). Addressing the Compartmentalization of Specific Integrin Heterodimers in Mouse Sperm. International Journal of Molecular Sciences, 20, 1004. https://doi.org/10.3390/ijms20051004
Georgadaki, K., Khoury, N., Spandidos, D. A., & Zoumpourlis, V. (2016). The Molecular Basis of Fertilization (Review). International Journal of Molecular Medicine, 38(4), 979–986. https://doi.org/10.3892/ijmm.2016.2723
Harjunpää, H., Llort Asens, M., Guenther, C., & Fagerholm, S. C. (2019). Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.01078
James, E. R., Carrell, D. T., Aston, K. I., Jenkins, T. G., Yeste, M., & Salas-Huetos, A. (2020). The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction. International Journal of Molecular Sciences, 21(15), 5377. https://doi.org/10.3390/ijms21155377
Jia, T. (2016). Definition of Bifunctional Theranostic Molecules for Cancer Treatment. Université Grenoble Alpes.
Machaty, Z., Miller, A. R., & Zhang, L. (2017). Egg Activation at Fertilization (pp. 1–47). https://doi.org/10.1007/978-3-319-46095-6_1
Merc, V., Frolikova, M., & Komrskova, K. (2021). Role of Integrins in Sperm Activation and Fertilization. International Journal of Molecular Sciences, 22(21), 11809. https://doi.org/10.3390/ijms222111809
Miyado, M., Kang, W., Kawano, N., & Miyado, K. (2019). Microexosomes versus exosomes : Shared components but distinct structures. Regenerative Therapy, 11, 31–33. https://doi.org/10.1016/j.reth.2019.04.013
Prihyugiarto, T., & Setyonaluri, D. (2018). Pola Determinan Fertilitas Menurut Provinsi, Indonesia: 2007-2012. Jurnal Keluarga Berencana, 3(1), 24–34. https://doi.org/10.37306/kkb.v3i1.5
Reid, A. T., Redgrove, K., Aitken, R. J., & Nixon, B. (2011). Cellular mechanisms regulating sperm–zona pellucida interaction. Asian Journal of Andrology, 13(1), 88–96. https://doi.org/10.1038/aja.2010.74
Sari, U. M., Koroy, T. R., Fahrianta, R. Y., Ramlan, R., & Oktriyanto, O. (2020). Peran Tingkat Intensi Memiliki Anak Sebagai Determinan Kebutuhan Keluarga Berencana Yang Belum Terpenuhi . Jurnal Keluarga Berencana, 5(2), 21–32. https://doi.org/10.37306/kkb.v5i2.45
Suherman, S., & Siregar, B. A. (2017). Pengetahuan Kesehatan Reproduksi Remaja Pelajar SLTP di Kecamatan Monta Kabupaten Bima Nusa Tenggara Barat 2016. Jurnal Kedokteran Dan Kesehatan, 13(1), 48. https://doi.org/10.24853/jkk.13.1.48-54
Tourmente, M., Sansegundo, E., Rial, E., & Roldan, E. R. S. (2022). Capacitation promotes a shift in energy metabolism in murine sperm. Frontiers in Cell and Developmental Biology, 10. https://doi.org/10.3389/fcell.2022.950979
Vernaz, Z. J., Lottero-Leconte, R. M., Alonso, C. A. I., Rio, S., Morales, M. F., Arroyo-Salvo, C., Valiente, C. C., Lovaglio Diez, M., Bogetti, M. E., Arenas, G., Rey-Valzacchi, G., & Perez-Martinez, S. (2022). Evaluation of Sperm Integrin α5β1 as a Potential Marker of Fertility in Humans. Plos One, 17(8), 1–15. https://doi.org/10.1371/journal.pone.0271729
Yuniarifa, C., Hussaana, A., & Riza, M. (2022). Perbedaan Efek Pemberian Secara Kombinasi dan Tunggal Ekstrak Biji Anggur (Vitis Vinifera l.) dan Glutation terhadap Motilitas, Jumlah, dan Morfologi Sperma Tikus Wistar yang Diberi Paparan Asap Rokok. Biomedika, 14(1), 20–32. https://doi.org/10.23917/biomedika.v14i1.13449
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Noer Aziza, Dwi Ari Pujianto
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
